Weakly supervised segmentation of COVID-19 infection with local lesion coherence on CT imagesResearch article Published on 2023-01-012022-10-05 Journal: Biomedical Signal Processing and Control [Category] 진단, 치료기술, [키워드] absence Accuracy Algorithm approach Attention automated chain Characteristics Clinical diagnosis Complete complex Computed tomography COVID-19 COVID-19 infection CT scan dataset deep learning diagnostic edge effective expression gold standard help IMPROVE individual information labeling labor-intensive lesion Local Local Coherence Lung infection module Novel coronavirus offer overcome public health reaction Region RT-PCR scale seeking Segmentation severity the disease time-consuming Weakly Supervised [DOI] 10.1016/j.bspc.2022.104099 [Article Type] Research article
Synthesis of new Spiropyrazole derivatives under microwaves irradiation and docking study for inhibition the microbes and COVID-19Research article Published on 2022-12-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] 6LU7 addition analysis antimicrobial Antiviral binding Candida albican Complete Complexes COVID-19 derivative derivatives docking docking score docking study domain Effectiveness Hydrazonoyl halides indicated inhibit Interaction Laboratory microbe microwave Microwaves physicochemical property protease Seven Spiropyrazoles synthesis tested these compound with COVID-19 [DOI] 10.1016/j.molstruc.2022.133581 [Article Type] Research article
Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trialArticle Published on 2022-12-012022-10-06 Journal: The Lancet Regional Health - Western Pacific [Category] 진단, [키워드] acute respiratory syndrome Administered Adults adverse event AEs age analysis assessment assigned BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine China Chinese clinical trial Complete Completed conducted coronavirus COVID-19 development dose double-blind Efficacy and safety enrolled Follow-up geometric mean titer GMT GMTs Han Chinese healthy immune response immunogenicity immunogenicity endpoint Inc independent individual injection intramuscular Intramuscular injection investigators Laboratory parameters management messenger Messenger RNA Mild moderate mRNA vaccine Neutralising Antibodies neutralising antibody of BNT162b2 participant Participants pharmaceutical Placebo placebo-controlled trial randomisation randomised Randomly reactogenicity receive recipients recruited reduced remained reported resolved Result robust Safety SARS-CoV-2 SARS-CoV-2 variant SCR second dose sera serious AE seroconversion rate severity Shanghai Sponsor statisticians stratified T-cell Response the placebo group Tolerability Treatment Trial utilised vaccination vaccination. vaccine administration were blinded [DOI] 10.1016/j.lanwpc.2022.100586 PMC 바로가기 [Article Type] Article
Effects of boosted mRNA and adenoviral-vectored vaccines on immune responses to omicron BA.1 and BA.2 following the heterologous CoronaVac/AZD1222 vaccinationArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome addition adenoviral-vectored vaccine antibody AZD1222 binding antibody BNT162b2 booster booster vaccination Booster vaccine comparable Complete coronavirus Coronavirus 2019 COVID-19 demonstrated develop dose Effect enrolled enzyme-linked immunosorbent Heterologous highest immune evasion immune response Immunogenicity analysis individual induce interferon-γ Messenger RNA Mild moderate mRNA mRNA vaccine mRNA-1273 mutations NAb titer NAbs neutralization neutralize Neutralizing Neutralizing activity neutralizing antibody observé Omicron variant Omicron. overcome participant raise receive receiving reduction response Serious Adverse Events significant increase Spike protein T-cell activation T-cell Response T-cell responses vaccination Vaccine waning immunity was recorded were measured [DOI] 10.1002/jmv.28044 PMC 바로가기
Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDSSARS-CoV-2에 의해 유발된 ARDS 생존자의 폐 기능 및 방사선학적 특징과 관련된 순환 microRNA 프로파일 식별Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory distress syndrome Anti-inflammatory ARDS association carbon monoxide cell death Chest computed tomography circulating Coagulation Complete composed Computed tomography conducted correlated COVID-19 develop diffusing diffusing capacity distress enrichment analyses enrichment analysis evaluated Evidence evidence of feature Features Follow-up Gene ontology genomes hospital discharge hypoxia identification immune response infected patient infected patients KEGG KEGG pathway Kyoto lung Lung function median microRNA miR-126 miR-146 miR-146a-5p miR-21 miR-9 miRNA miRNA profiles miRNA profiling miRNA signature molecular molecular mechanism molecular mechanisms Pathogenesis pathophysiology pathway Patient patients predicted profile provided Pulmonary function radiologic radiological feature radiological features Random forest respiratory distress Respiratory distress syndrome RT-qPCR SARS-COV-2 infection secondary to sequelae severe COVID-19 severity survivor to define total severity score. Trial registration TSS vascularization viral infection was performed was used [DOI] 10.1080/22221751.2022.2081615 PMC 바로가기 [Article Type] Article
Sudden unexpected death in a 17-year-old boy due to unacknowledged adamantinoma-like Ewing sarcomaArticle Published on 2022-12-012022-11-15 Journal: Forensic Science, Medicine, and Pathology [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, [키워드] Abnormalities Adamantinoma-like Ewing sarcoma addition airway Airway occlusion Analysis analysis anatomical Autopsy Blood Brain break cardiac cause CD99 Cell characterized Chest radiography Complete death diagnosed diagnostic diagnostics died discharged disease Dyspnea EWSR1 excluded expression Forensic Forensic autopsy forensic pathology Germany histopathological hospital immunohistochemistry Invasion Leica Local lung macroscopic male mechanism Microscopy Mild molecular Nasopharyngeal swab neoplasm nucleoli organ oxygen saturation pathology probe SARS-CoV-2 Soft tissue subject sudden Sudden unexpected death. tested Thyroid was performed [DOI] 10.1007/s12024-022-00525-x PMC 바로가기
Additively manufactured electrodes for the electrochemical detection of hydroxychloroquineArticle Published on 2022-12-012022-11-16 Journal: Talanta [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation addition Additive Additive manufacturing Analysis applicability aquatic environments Cell Complete Concentration confidence level contaminant coronavirus demonstrated Electroanalysis FDM Fused filament fabrication HCQ hospitalized patient Hydroxychloroquine limit of detection linear organization pandemic Precision SARS-CoV-2 sensors. shown Tablet tap Treatment [DOI] 10.1016/j.talanta.2022.123727 PMC 바로가기
Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvantsArticle Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 진단, [키워드] abrogated ACE2 addition adjuvant adjuvants Adsorption alum aluminum analysis Antigen approach binding booster Combination Complete conformational Coverage COVID-19 COVID-19 vaccine CpG decrease demonstrated destabilized domain dose ELISA exacerbated facilitate Formulation highlight host cell receptor immune responses immunogenicity IMPROVE in vitro in vivo Interaction interactions mice neutralize neutralizing antibody profile Protein RBD RBD antigen SARS-CoV-2 SARS-CoV-2 pseudovirus spike stability stability profile subunit vaccines temperature the receptor-binding domain Vaccine vaccine. while [DOI] 10.1080/21645515.2022.2079346 PMC 바로가기
Multiple genome analytics framework: The case of all SARS-CoV-2 complete variantsArticle Published on 2022-11-202022-11-16 Journal: Journal of biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accelerated Algorithm Algorithms analyses analytics ARPaD bioinformatics Biotechnology can be used center Comparisons Complete computational tool COVID-19 dataset Efficiency framework Genome genome sequence genomic help information introduced knowledge LERP-RSA meta-analyses MPaD MuGA Multiple Multiple genome analytics framework organism palindrome pattern polymerase chain primer problem problems question repeated required resource resources SARS-CoV-2 SARS-CoV-2 genome sequence sequence SPaD. Structure text mining Topic variant variants [DOI] 10.1016/j.jbiotec.2022.09.015 PMC 바로가기
Acquired Thrombotic Thrombocytopenic Purpura After BNT162b2 COVID-19 Vaccine: Case Report and Literature ReviewArticle Published on 2022-11-032022-11-15 Journal: Laboratory medicine [Category] 진단, [키워드] Acquired ADAMTS Anemia autoantibody Blood BNT162b2 BNT162b2 vaccine caplacizumab caused Complete COVID-19 COVID-19 vaccine deficiency Diagnosis gastrointestinal symptoms immunosuppressive literature microangiopathy MOST occurred outcome Patient patients Pfizer-BioNTech plasma positive Prednisone presenting report reported review second dose significantly the patient therapy thrombocytopenia thrombosis thrombotic Thrombotic thrombocytopenic purpura treated Treatment Vaccine vaccine. was used [DOI] 10.1093/labmed/lmac016 PMC 바로가기